The Long Game

Longevity science, separated from the longevity industry

Lucas Ferreira2 episodes1 min of audio91 playsEpisodic

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S1 · E2Aug 29, 20260:4445 plays Preview

Rapamycin, from mice to humans

Pharmacologist Dr Ingrid Weber joins Lucas to explain what rapamycin does, why it extends lifespan in mice, what the small human trials show, and why he would not prescribe it yet.

S1 · E1May 18, 20260:4446 plays Members

Does VO2 max predict how long you live

Lucas examines the headline that cardiorespiratory fitness is the strongest predictor of mortality, explains what the large cohort studies measured, and sets out how much cardio actually moves the nee…

About the show

The Long Game is a fortnightly show that reads the ageing research so you do not have to, hosted by Dr Lucas Ferreira, a geriatrician and clinical researcher in Sao Paulo. Each 45-minute episode takes one claim from the longevity world, such as rapamycin, NAD supplements, VO2 max as a predictor of lifespan, calorie restriction, grip strength, zone 2 cardio, and traces it back to the actual studies, the animal models, the human trials and the gaps. Lucas interviews researchers, reads the papers aloud where it matters, and is frank about what is promising, what is premature, and what is simply expensive. He also brings in the unglamorous findings: social connection, sleep, muscle mass, blood pressure control. The show is for curious adults who want to age well without buying a subscription to anything. Expect nuance, a bit of Brazilian humour, and clear verdicts at the end of every episode.

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