Rapamycin, from mice to humans
Pharmacologist Dr Ingrid Weber joins Lucas to explain what rapamycin does, why it extends lifespan in mice, what the small human trials show, and why he would not prescribe it yet.
Does VO2 max predict how long you live
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Show notes
The fitness and mortality studies
You have probably heard that VO2 max beats smoking, diabetes and blood pressure as a predictor of death. Lucas goes to the source, explains what the cohorts measured and who was in them, and asks the practical question: how fit is fit enough.
- The 2018 Cleveland Clinic study and what it did not show
- Correlation, causation and the problem of sick people exercising less
- How much improvement is realistic after 50
- Zone 2 and intervals: what the evidence prefers
- Lucas's verdict on a scale of promising to proven
Next episode, a researcher on rapamycin in humans.
Transcript
Ola, bem-vindos. I am Dr Lucas Ferreira, I am a geriatrician in Sao Paulo, and this is The Long Game, where we read the longevity research so you do not have to pay for a course about it. Today's question is one you have seen in a hundred posts. Is VO2 max really the strongest predictor of how long you will live. The claim comes from real studies, big ones, and I am going to walk you through what they actually measured, who was in them, and the one problem with the data that almost nobody mentions. Then the useful part: how fit do you need to be, how much can you improve after 50, and what kind of cardio the evidence prefers. At the end I will give you a verdict. You are listening on Witspeak Podcasts.
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