Does VO2 max predict how long you live
Lucas examines the headline that cardiorespiratory fitness is the strongest predictor of mortality, explains what the large cohort studies measured, and sets out how much cardio actually moves the nee…
Rapamycin, from mice to humans
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Show notes
The most hyped molecule in longevity
Rapamycin extends the lifespan of mice in every lab that has tried it, and a growing number of people are taking it off-label. Dr Ingrid Weber, a clinical pharmacologist, explains the mechanism, the human data and the risks with Lucas.
- What mTOR is and why switching it down matters
- The mouse studies and why mice are not small humans
- The PEARL trial and other small human studies
- Side effects: mouth ulcers, immunity and blood sugar
- Why Lucas and Ingrid both say wait for better trials
The papers discussed are listed in the show notes.
Transcript
Welcome back to The Long Game. I am Lucas Ferreira. Today we are talking about rapamycin, the drug that makes mice live longer and that a surprising number of healthy people are now taking every week, on their own initiative, because of what they read online. To help me I have Dr Ingrid Weber, a clinical pharmacologist who has spent her career on exactly this class of drugs. We will explain what rapamycin does inside a cell, why it works so well in mice, what the handful of human trials have actually found, and the side effects that do not make it into the posts. And I will tell you honestly whether I would take it myself. Ingrid, welcome to the show. You are listening on Witspeak Podcasts.
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